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Lung Treatment with Cesium-131 Brachytherapy Seeds

The GilaSite Radiation Therapy System (RTS) is intended for use in the management of surgically resectable brain tumors where adjuvant radiation therapy of the post-resection tissue bed is indicated.

Over 200 Gilasite RTS cases have been detailed in the peer-reviewed literature in reports from multi-institutional studies and academic centers.*

Brain cancers treated in these reports include primary and recurrent gilomas, as well as resectable metastatic brain tumors.*

GilaSite RTS is well-tolerated and compares favorably to other management strategies when used as adjuvant radiation therapy in conjunction with surgical resection.*

Over 2,000 patients have been treated with GilaSite RTS to date.

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GilaSite Information:

Each IsoRay GilaSite RTS includes:

• 2, 3, or 4 cm Dual Lumen Ballon-Catheter Assembly  1

• Infusion Set

• Access Tray

• Iotrex Soultion  2

Iotrex Information:

Each vial of Iotrex contains 195 mCi of l-¹²⁵ as Sodium-3-(¹²⁵I)iodo-4-Hydroxybenzenesulfonate

 

Published References: *

1. Wernicke AG, Sherr DL, Schwartz TH, et al, The role of dose escalation with intracavitary brachytherapy in the treatment of localized CNS malignancies: outcomes and toxciities of a prospective study. Brachytherapy. Jan-Mar 2010;9(1); 91-99.
2. Wernicke AG, Sherr DL, Schwartz TH, et al, Feasibility and safety of Gilasite brachytherapy in treatment of CNS tumors following neurosurgical resection. J Cancer Res Ther. Jan-Mar 2010;6(1):65-74.
3. Kleinberg L. Yoon G. Weigart JD, et al, Imaging after GilaSite Brachytherapy; prognostic MRI indicators of disease control and recurrence. Int J Ratiat Oncol Biol Phys. Dec 1 2009;75(5):1285-1391.
4. Chan, TA., Weigart JD, Parisi M. et al, Treatment of Recurrent glioblastoma multiforme with GliaSite Brachytherapy, Int. J. Radiation Oncology Biol. Phys. Jul 15 2005;62(4):1133-1139.
5. Chino K, Silvain D, Stubbs J, Stea B. Feasibility and safety of outpatient brachytherapy in 37 patients with brain tumors using the GilaSite Radiation Therapy System. Med Phys. Jul 2009;35(7):3383-3388
6. Gabayan, AJ,Green SB, Sanan A, et al, GliaSite brachytherapy for treatment of recurrent malignant gliomas: a retrospective multi-institutional analysis, Neurosurgery Apr 2006;58(4):701-708. 7. Welsh J, Sanan A, Gabayan AJ, et al, GliaSite brachytherapy boost as part of initial treatment of glioblastoma multiforme; a retrospective multi-institutional pilot study. Int J Ratiat Oncol Biol Phys. May 1 2007;68(1):159-165. 8. Rogers, LR, Rock JP, Sillis AK, et al, Results of a phase ii trial of the GliaSite Radiation therapy system for treatment of newly diagnosed brain metastases, J. Neurosurgery. Sep 2006;105(3):375-384
9. Tatter SB, Shaw EG, Rosenblum ML, et al, An inflatable ballon catheter and liquid ¹²⁵I radiation source (GilaSite Radiation Therapy Suystem) for treatment of recuirrent malignant gilioma; multicenter saftey and feseability trial. J Neurosurg. Aug 2003;99(2):297-303

 1 Ballon size dependent upon size of resection cavity

 2  Iotrex solution delivered by radiopharmacy to operating facility on date of surgery